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退休教師

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鄭益謙 教授

教授
研究室
獸醫臨床微生物及單源抗體研究室（獸一館311R）
聯絡資訊
（02）3366-9912
ivancheng@ntu.edu.tw
研究領域
以單源抗體(monoclonal antibody, MAb)為工具之口蹄疫(FMD)、豬水疱病(SVD)等動物水疱性疾病病毒預防醫學研究。目的：非結構蛋白抗體診 斷試劑、中和抗體檢測試劑之研發，及致病機制(pathogenesis)等之研究。 以融合瘤技術平臺與其它研究單位合作，研發針對動物病毒具特異性之MAb，進行疾病診斷、致病機制(pathogenesis)等研究。
學、經歷
美國佛羅里達大學比較及實驗病理系博士
詳細內容
擔任課程  |  獸醫遺傳學、反芻動物疾病學、免疫遺傳、豬病學
Office hours  | 星期一14:00-17:00 （請同學先以Email方式與老師約定時間）
學術發表
序 性質 篇名/作者
1. 期刊論文 Hung L. C., Y. H. Huang, Y. S. Lai, W. C. Lee, Y. L. Lin, and I. C. Cheng*. 2016. Humoral Immunity of TLRI Black Pig and the Effect of PCV2 subunit vaccination into It [畜試黑豬之體液免疫及接種環狀病毒次單位疫苗之研究]. 中國畜牧協會會誌 (J. Chin. Soc. Anim. Sci.). 45(3):245-261.
2. 期刊論文 Yang C., Y. C. Chang, C. Y. Chang, P. S. Tsai, C. R. Jeng, V. F. Pang, I. C. Cheng, and H. W. Chang. 2016. Identification of a highly transfectable cell line permissive to PEDV infection and replication. Taiwan Vet J. 42(4):187-193.
3. 期刊論文 Huang Y.P., Wang C.H., and I.C. Cheng*. 2013. Monitoring of Avian Influenza Virus in Imported Poultry Products during Year 2005-2008. Taiwan Vet. J. 39(3): 166-173.
4. 期刊論文 Hong H.W., I.C. Cheng, H.W. Chen, and C.H. Wang*. 2012. Comparison of NP and M Primers for Avian Influenza Virus Detection by Reverse Transcription Polymerase Chain Reaction. Taiwan Vet J. 38(4):213-220.
5. 期刊論文 Chen, H.W., Wang, C.H., *Cheng, I.C. 2011 (April)：A type-specific blocking ELISA for the detection of infectious bronchitis virus antibody. J. Virol. Methods 173:7–12 （SCI）
6. 期刊論文 Yang, S.Y., Wang, W.C., Lan, C.B., Chen, C.H., Chieh, J.J., *Horng, H.E., Hong, Chin-Yih, Yang, H.C., Tsai, C.P., Yang, C.Y., Cheng I.C., Chung W.C. 2010 (March)：Magnetically enhanced high-specificity virus detection using bio-activated magnetic nanoparticles with antibodies as labeling markers. J. Virol. Methods 164:14–18 （SCI）
7. 期刊論文 Chen, S.P., Sun, Y.F., Lee, M.C., Cheng, I.C., Yang, P.C., Huang, T.S., Jong, M.H., Robertson, I. D., Edward, J. R., *Ellis, T. M. 2008 (1 January)：Immune responses to foot-and-mouth disease virus in pig farms after the 1997 outbreak in Taiwan. Vet. Microbiol. 126（1-3）:82–90. （SCI）
8. 期刊論文 Chen, S.P., Lee, M.C., Sun, Y.F., Cheng, I.C., Yang, P.C., Lin, Y.L., Jong, M.H., Robertson, I. D., Edward, J. R., *Ellis, T. M. 2007 (May 30)：Immune responses of pigs to commercialized emulsion FMD vaccines and live virus challenge. Vaccine. 25（22）:4464–4469. （SCI）
9. 期刊論文 Kim, S.A., Liang, C.M., Cheng, I.C., Cheng, Y.C., Chiao, M.Y., Tseng, C.J., Lee, F., Jong, M.H., *Liang, S.-M. 2006：DNA Vaccination against Foot-and-Mouth Disease via Electroporation : Study of Molecular Approaches for Enhancing VP1 Antigenicity. The Journal of Gene Medicine 8（9）:1182-1191. （SCI）
10. 期刊論文 *Cheng, I.C., Liang, S.M., Tu, W.J., Chen, C.M., Lai, S.Y., Cheng, Y.C., Lee, F., Huang, T.S., Jong, M.H. 2006：Study on the Porcinophilic Foot-and-Mouth Disease Virus. I. Production and Characterization of Monoclonal Antibodies against VP1. Journal of Veterinary Medical Science 68（8）:859-864. （SCI）
11. 期刊論文 李明昌、鄭益謙、蔡清恩、林有良、陳靜美、鍾明華、*陳世平。 2004：口蹄疫母體移行抗體對仔牛疫苗免疫反應之影響。 台灣獸醫誌 30（3）:200-205.
12. 期刊論文 Liao, C.W., Cheng, I.C., Yeh, K.S., Lin, F.Y., *Weng, C.N. 2001： Release characteristics of microspheres prepared by co-spray drying Actinobacillus pleuropneumoniae antigens and aqueous ethyl-cellulose dispersion. J. Microencapsulation 18(3）:285-297. （SCI）
13. 期刊論文 *朱瑞民、 楊平政、 鄭益謙。 1997： 綜說：口蹄疫。 中華獸醫誌 23：477-491.
14. 期刊論文 Chesnut, K., She, J.-X., Cheng, I.C., Muralidharan, K., *Wakeland, E.K., 1993： Characterizations of Candidate Genes for IDD Susceptibility from the Diabetes-prone NOD Mouse Strain. Mammalian Genome 4:549-554.（SCI）
15. 期刊論文 鄭益謙, 朱瑞民。 1990： 豬腸繫膜淋巴結內淋巴球於體內之運轉。 中華獸醫誌 16:365-374.
16. 期刊論文 *Wakeland, E.K., Boehme, S., She, J.-X., Lu, C.-C., McIndoe, R.A., Cheng, I.C., Ye, Y., Potts, W.K., 1990： Ancestral Polymorphisms of MHC Class II Genes: Divergent Allele Advantage. Immunologic Research 9:123.（SCI）
17. 期刊論文 *Siegelman, M.H., Cheng, I.C., Weissman, I.L., Wakeland, E.K., 1990： The Mouse Lymph Node Homing Receptor is Identical with the Lymphocyte Cell Surface Marker Ly-22: Role of the EGF Domain in Endothelial Binding. Cell 61:611-622.（SCI）
18. 期刊論文 Chen K. Y., I. C. Cheng, and C. H. Wang*. 2016. Immunochromographic Strip Using Baculovirus Expression Nucleoprotein to Detect Avian Influenza Antibody. 台灣農學會報 (Journal of the Agricultural Association of Taiwan). 17(1):76-86.
19. 期刊論文 Hung L. C., C. Y. Yang, and I. C. Cheng. 2017. Peptides mimicking viral proteins of porcine circovirus type 2 were profiled by the spectrum of mouse anti-PCV2 antibodies. BMC Immunol. 18(25):18-25. (SCI)
20. 期刊論文 Hung L. C. and I. C. Cheng. 2017. Versatile carboxyl-terminus of capsid protein of porcine circovirus type 2 were recognized by monoclonal antibodies with pluripotency of binding. Mol. Immunol. 85:100-110. (SCI)
21. 期刊論文 Chang Y. C., C. F. Kao, C. Y. Chang, C. R. Jeng, P. S. Tsai, V. F. Pang, H. Y. Chiou, J. Y. Peng, I. C. Cheng, and H. W. Chang. 2017. Evaluation and Comparison of the Pathogenicity and Host Immune Responses Induced by a G2b Taiwan Porcine Epidemic Diarrhea Virus (Strain Pintung 52) and Its Highly Cell-Culture Passaged Strain in Conventional 5-Week-Old Pigs. Viruses. 9(5):121-135.
22. 期刊論文 Kao C. F., H. Y. Chiou, C. Y. Chang, C. S. Hsueh, C. R. Jeng, P. S. Tsai, I. C. Cheng, V. F. Pang, J. Y. Peng, and H. W. Chang. 2018：The characterization of immunoprotection induced by a cDNA clone derived from the attenuated Taiwan Porcine Epidemic Diarrhea Virus Pintung 52 strain. Viruses. 10(10):543-557（SCI）
23. 期刊論文 Peng J. Y., C. Y. Chang, C. F. Kao, Y. C. Chang, C. S. Hsueh, C. R. Jeng, I. C. Cheng, V. F. Pang, P. S. Tsai, and H. W. Chang. 2018. Different intestinal tropism of the G2b Taiwan Porcine Epidemic Diarrhea virus-Pintung 52 strain in conventional 7-day-old piglets. Vet. J. 237:69-75. (SCI)
24. 期刊論文 Lee H. W., M. C. Deng, C. H. Pan, H. W. Chang, and I. C. Cheng. 2018. Neutralizing monoclonal antibodies against porcinophilic Foot-and-mouth disease virus mapped to antigenic site 2 by utilizing novel mutagenic virus-like particles to detect the antigenic change. Vet. Microbiol. 222:124–131. (SCI)
25. 期刊論文 Liu I. L., Y. C. Lin, Y. C. Lin, C. Z. Jian, I.C. Cheng*, H. W. Chen. 2019. A Novel Immunochromatographic Strip for Antigen Detection of Avian Infectious Bronchitis Virus. Int. J. Mol. Sci. 20(9)2216. (SCI)
26. 期刊論文 Chang C. Y., I. C. Cheng, Y. C. Chang, P. S. Tsai, S. Y. Lai, Y. L. Huang, C. R. Jeng, V. F. Pang, and H. W. Chang*. 2019. Identification of Neutralizing Monoclonal Antibodies Targeting Novel Conformational Epitopes of the Porcine Epidemic Diarrhea Virus Spike Protein. Sci. Rep. 9(1):2529. (SCI)
27. 期刊論文 Tu Y. C., K. Y. Chen, C. K. Chen, M. C. Cheng, S. H. Lee, and I.C. Cheng*. 2019. Novel application of Influenza A virus-inoculated chorioallantoic membrane to characterize a NP-specific monoclonal antibody for immunohistochemistry assaying. J. Vet. Sci. 20(1):51-57. (SCI)
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