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專任教師

  1. 專任教師

張晏禎 副教授

副教授
研究室
分子免疫病理學實驗室 Molecular Immunology and Pathology Lab
聯絡資訊
（02）33663873 (office), (02) 33669899 (lab)
yenchenchang@ntu.edu.tw
研究領域
病毒分子致病機制、動物用疫苗研發、獸醫病理學
學、經歷
國立臺灣大學獸醫學博士
詳細內容
擔任課程  |  獸醫病理學及實習、屍體解剖學、組織病理診斷學、獸醫診斷病理學、分子病理生物學
Office hours  | 請同學以Email方式與老師約定時間; 歡迎大三以上獸醫系同學及研究生對獸醫診斷病理及疫苗學有興趣者加入實驗室。
學術發表
序 性質 篇名/作者
1. 期刊論文 Wang HY, Wu MC, Chen HW, Lai YC, Huang WH, Chang HW, Jeng CR, Cheng CH, Wang PJ, Lai YH, Chang YC. Isolation, full sequence analysis, and in situ hybridization of pigeon paramyxovirus-1 genotype VI.2.1.1.2.2 from oriental turtle doves (Streptopelia orientalis). (2023) Poultry Science, 102(10): 102974. DOI: 10.1016/j.psj.2023.102974
2. 期刊論文 Lu CH, Yu SH, Wu CH, Yeh J LS, Chang HW, Jeng CR, Chang YC. Effects of selective cyclooxygenase-2 inhibitor robenacoxib on primary cells derived from feline injection-site sarcoma. (2023) Journal of Cellular and Molecular Medicine, 27(15):2183-2193. doi: 10.1111/jcmm.17717
3. 期刊論文 Hsu CW, Wang PJ, Huang PY, Lien CY, Wu LH, Lai YH, Guo JC, Chang YC, Cheng CH, Chang HW. Molecular and serological detection of Toxoplasma gondii infection in mammals in the Taipei Zoo. (2022) Zoonoses and public health, 69(8):904-914. DOI: 10.1111/zph.12987
4. 期刊論文 Lee CF, Chang YC, Chiou HY, Chang HW. Concurrent infection of a novel genotype of hepatopancreatic parvovirus and Enterocytozoon hepatopenaei in Penaeus vannamei in Taiwan. (2022) Journal of Fish Disease, 45(8):1201-1210. https://doi.org/10.1111/jfd.13655.
5. 期刊論文 Huang CY, Draczkowski P, Wang YS, Chang CY, Chien YC, Cheng YH, Wu YM, Wang CH, Chang YC, Chang YC, Yang TJ, Tsai YX, Khoo KH, Chang HW, Hsu STD. In situ structure and dynamics of an alphacoronavirus spike protein by cryo-ET and cryo-EM. (2022) Nature Communications, 13(1):4877. https://doi.org/10.1038/s41467-022-32588-3.
6. 期刊論文 Lee TW, Chao TY, Chang HW, Cheng YH, Wu CH, Chang YC. The Effects of Bacillus licheniformis-Fermented Products on the Microbiota and Clinical Presentation of Cats with Chronic Diarrhea. (2022) Animals, 12(17), 2187. https://doi.org/10.3390/ani12172187.
7. 期刊論文 Shih CH, Chang YC, Lai YC, Chiou HY. Investigating the role of signal transducer and activator of transcription 3 in feline injection site sarcoma. (2022) BMC Veterinary Research, 18:276. https://doi.org/10.1186/s12917-022-03352-y.
8. 期刊論文 Wei YS, Cheng HP, Wu CH, Chang YC, Lin RW, Hsu YT, Chen YT, Lin SL, Tsai SY, Wu SC, Tsai PS. Oxidative Stress-Induced Alterations of Cellular Localization and Expression of Aquaporin 1 Lead to Defected Water Transport upon Peritoneal Fibrosis. (2022) Biomedicines 202210(4), 810 https://doi.org/10.3390/biomedicines10040810.
9. 期刊論文 Chang CY, Wang YS, Wu JF, Yang TJ, Chang YC, Chae C, Chang HW, Hsu STD. Generation and Characterization of a Spike Glycoprotein Domain A- Specific Neutralizing Single-Chain Variable Fragment against Porcine Epidemic Diarrhea Virus. (2021) Vaccines, 9(8):833. https://doi.org/ 10.3390/vaccines9080833.
10. 期刊論文 Chang YC, Chang HW, Chiou HY, Jeng CR, Pang VF, Chang YC. Investigation of effects of porcine circovirus type 2 (PCV2) vaccination on cellular immunity in pigs in a Taiwan pig farm. (2021) Taiwan Veterinary Journal, 47(1), 7-15; https://doi.org/10.1142/S1682648521500025
11. 期刊論文 Chang YC, Chang HW, Chiou HY, Jeng CR, Pang VF, Chang YC. Investigation of effects of porcine circovirus type 2 (PCV2) vaccination on cellular immunity in pigs in a Taiwan pig farm. (2021) Taiwan Veterinary Journal, 47(1), 7-15; https://doi.org/10.1142/S1682648521500025
12. 期刊論文 Chen WT, Teng CA, Shih CH, Huang WH, Jiang YF, Chang HW, Jeng CR, Lai YH, Guo JC, Wang PJ, Cheng CH, Chang YC. (2021) Investigation of Lethal Concurrent Outbreak of Chlamydiosis and Pigeon Circovirus in a Zoo. Animals, 11(6), 1654. https://doi.org/ 10.3390/ani11061654.
13. 期刊論文 Hsu CW, Chang MH, Chang HW, Wu TY, Chang YC. Parenterally administered porcine epidemic diarrhea virus-like particle-based vaccine formulated with CCL25/28 chemokines induces systemic and mucosal immune protectivity in pigs. (2020) Viruses, 12(10), 1122; https://doi.org/10.3390/v12101122.
14. 期刊論文 Tung YC, Liang ZR, Chou SF, Ho CT, Kuo YL, Cheng KC, Lu TJ, Chang YC, Pan MH. Fermented Soy Paste Alleviates Lipid Accumulation in the Liver by Regulating the AMPK Pathway and Modulating Gut Microbiota in High-Fat-Diet-Fed Rats. (2020) Journal of Agricultural and Food Chemistry, 68, 35, 9345–9357
15. 期刊論文 Chang CY, Yamashita-Kawanishi N, Tomizawa S, Liu IL, Chen WT, Chang YC, Huang WH, Tsai PS, Shirota K, Chambers JK, Uchida K, Haga T, Chang HW. (2020) Whole Genomic Analysis and Comparison of Two Canine Papillomavirus Type 9 Strains in Malignant and Benign Skin Lesions. (2020) Viruses, 12(7):736; doi:10.3390/v12070736.
16. 期刊論文 Hsu YT, Wu CH, Chao CY, Wei YS, Chang YC, Chen YT, Lin SL, Tsai SY, Lee YJ, Tsai PS. Hypochlorite‑induced porcine model of peritoneal fibrosis through the activation of IL1β‑CX3CL1‑TGFβ1 signal axis. (2020) Scientific Reports, 10:11496
17. 期刊論文 Hsueh FC, Chang YC, Kao CF, Hsu CW, Chang HW. Intramuscular Immunization with Chemokine-Adjuvanted Inactive Porcine Epidemic Diarrhea Virus Induces Substantial Protection in Pigs. (2020) Vaccines, 24;8(1):102; doi:10.3390/vaccines8010102
18. 期刊論文 Hsueh FC, Lin CN, Chiou HY, Chia MY, Chiou MT, Haga T, Kao CF, Chang YC, Chang CY, Jeng CR, Chang HW. Updated Phylogenetic Analysis of the Spike Gene and Identification of a Novel Recombinant Porcine Epidemic Diarrhoea Virus Strain in Taiwan. (2020) Transboundary and Emerging Diseases, 67(1):417-430. DOI: 10.1111/tbed.13365.
19. 期刊論文 Yang TJ, Chang YC, Ko TP, Draczkowski P, Chien YC, Chang YC, Wu KP, Khoo KH, Chang HW, Hsu STD. Cryo-EM analysis of a Feline Coronavirus Spike Protein Reveals a Unique Structure and Camouflaging Glycans. (2020) Proceedings of the National Academy of Sciences of the United States of America (PNAS), 2020 117 (3) 1438-1446
20. 期刊論文 Chang CY, Peng JY, Cheng YH, Chang YC, Wu YT, Tsai PS, Chiou HY, Jeng CR, Chang HW. Development and comparison of enzyme- linked immunosorbent assays based on recombinant trimeric full-length and truncated spike proteins for detecting antibodies against porcine epidemic diarrhea virus. (2019) BMC Veterinary Research, 15:421. https://doi.org/10.1186/s12917-019-2171-7.
21. 期刊論文 Chia-Yu Chang, Ivan-Chen Cheng, Yen-Chen Chang*, Pei-Shiue Tsai, Seiu-Yu Lai, Yu-Liang Huang, Chian-Ren Jeng, Victor Fei Pang, and Hui-Wen Chang. Identification of Neutralizing Monoclonal Antibodies Targeting Novel Conformational Epitopes of the Porcine Epidemic Diarrhoea Virus Spike Protein. Scientific Reports, 9: 2529 (2019).
22. 期刊論文 Yen-Chen Chang*, Chia-Yu Chang, Pei-Shiue Tsai, Hue-Ying Chiou, Chian-Ren Jeng, Victor Fei Pang, Hui-Wen Chang. Efficacy of Heat-Labile Enterotoxin B Subunit-Adjuvanted Parenteral Porcine Epidemic Diarrhea Virus Trimeric Spike Subunit Vaccine in Piglets. Applied Microbiol Biotechnol; 102(17):7499-7507 (2018).
23. 期刊論文 Ju-Yi Peng, Chia-Yu Chang, Chi-Fei Kao, Yen-Chen Chang*, Cheng-Shun Hsueh, Chian-Ren Jeng, Ivan-Chen Cheng, Victor Fei Pang, Pei-Shiue Tsai, Hui-Wen Chang. Different Intestinal Tropism of the G2b Taiwan Porcine Epidemic Diarrhea Virus-Pintung 52 Strain in Conventional 7-Day-Old Piglets. The Vet J, 237: 69-75 (2018).
24. 期刊論文 Chi-Fei Kao, Hue-Ying Chiou, Yen-Chen Chang*, Cheng-Shun Hsueh, Chian-Ren Jeng, Pei-Shiue Tsai, Ivan-Chen Cheng, Victor Fei Pang and Hui-Wen Chang. The Characterization of Immunoprotection Induced by a cDNA Clone Derived from the Attenuated Taiwan Porcine Epidemic Diarrhea Virus Pintung 52 Strain. Viruses, 10(10), 543 (2018).
25. 期刊論文 Yen-Chen Chang*, Chi-Fei Kao, Chia-Yu Chang, Chian-Ren Jeng, Pei-Shiue Tsai, Victor Fei Pang, Hue-Ying Chiou, Ju-Yi Peng, Ivan-Chen Cheng, Hui-Wen Chang. Evaluation and Comparison of the Pathogenicity and Host Immune Responses Induced by a G2b Taiwan Porcine Epidemic Diarrhea Virus (Strain Pintung 52) and Its Highly Cell-Culture Passaged Strain in Conventional 5-Week-Old Pigs. Viruses, 9, 121 (2017). *Co-first author.
26. 期刊論文 Tat-Chuan Cham, Yen-Chen Chang*, Pei-Shiue Tsai, Ching-Ho Wu, Hui-Wen Chen, Chian-Ren Jeng, Victor Fei Pang, Hui-Wen Chang. Determination of the cell tropism of serotype 1 feline infectious peritonitis virus using the spike affinity histochemistry in paraffin-embedded tissues. Microbiol Immunol; 61: 318–327 (2017). *Co-first author.
27. 期刊論文 Ching Yang, Yen-Chen Chang*, Chia-Yu Chang, Pei-Shiue Tsai, Chian-Ren Jeng, Victor Fei Pang, Ivan-Chen Cheng, Hui-Wen Chang. Identification of A Highly Transfectable Cell Line Permissive to Porcine Epidemic Diarrhea Virus Infection and Replication. Taiwan Vet J, Vol. 42, 187 (2016).
28. 期刊論文 Yen-Chen Chang*, Chian-Ren Jeng, Victor Fei Pang, Yen-Hsueh Lai, Chen-Yeh Lien, Pao-Jung Wang, Chun-Cheng Guo, Hui-Wen Chang. Post-anesthesia hiatus hernia in a Bengal tiger (Panthera tigris tigris). Taiwan Vet J, 42, 171 (2016).
29. 期刊論文 Yen-Chen Chang*, Chian-Ren Jeng, Victor Fei Pang. Comparisons on the responses of peripheral blood mononuclear cells to mitogen stimulation and porcine circovirus type 2 (PCV2) superinfection in vitro in subclinically PCV2-infected pigs under different PCV2 vaccination condition and serum PCV2 loads. Master thesis (2014).
30. 期刊論文 Kuo SH, Chang YC, Chang HW, Huang WH. Detection of spike- specific mutations in serotype I feline coronaviruses in formalin-fixed paraffin-embedded tissue. (2020) Taiwan Veterinary Journal, 46 (2): 111-122 https://doi.org/10.1142/S1682648520720026.
31. 期刊論文 Peng JY, Horng YB, Wu CH, Chang CY, Chang YC, Tsai PS, Jeng CR, Cheng YH, Chang HW. Evaluation of antiviral activity of Bacillus licheniformis-fermented products against porcine epidemic diarrhea virus. (2019) AMB Express, 9:191 https://doi.org/10.1186/s13568-019-0916-0.
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