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專任教師

  1. 專任教師

陳慧文 副院長

獸醫專業學院教授兼副院長
研究室
傳染病與免疫實驗室（獸一館101R）
聯絡資訊
02-33669450
winnichen@ntu.edu.tw
研究領域
抗病毒藥物與疫苗之研發、病毒之致病與免疫機制、傳染病流行病學、微生物診斷方法開發
學、經歷
國立臺灣大學獸醫學博士 (2010)
University of California San Diego 醫學院 博士後研究 (-2012)
La Jolla Institute for Allergy and Immunology 疫苗開發部 博士後研究 (-2013)
詳細內容
實驗室網頁  |  https://www.winnichen.net/
擔任課程  |  獸醫病毒學及實習、獸醫免疫學、禽病學、病毒之感染與免疫專題討論
Office hours  | 請同學以Email方式與老師預約時間
連結  | 動物病原檢驗服務
學術發表
序 性質 篇名/作者
1. 期刊論文 Hu CMJ, Chen YT, Fang ZS, Chang WS, Chen HW*. Antiviral efficacy of nanoparticulate vacuolar ATPase inhibitors against influenza virus infection. International Journal of Nanomedicine doi:10.2147/IJN.S185806, 2018. (*corresponding) .
2. 期刊論文 Chen HW, Fang ZS, Chen YT, Chen YI, Yao BY, Cheng JY, Chien CY, Hu CMJ. Targeting and Enrichment of viral pathogen by cell membrane cloaked magnetic nanoparticles for enhanced detection. ACS Applied Materials & Interfaces doi:10.1021/acsami.7b09931, 2017.
3. 期刊論文 Hu CMJ, Chang WS, Fang ZS, Chen YT, Wang WL, Tsai HH, Chueh LL, Takano T, Hohdatsu T, Chen HW.. Nanoparticulate vacuolar ATPase blocker exhibits potent host targeted antiviral activity against feline coronavirus. Scientific Reports doi:10.1038/s41598-017-13316-0, 2017.
4. 期刊論文 Lin SY, Chen HW. Infectious bronchitis virus variants: molecular analysis and pathogenicity investigation. International Journal of Molecular Sciences doi:10.3390/ijms18102030, 2017.
5. 期刊論文 Cham TC, Chang YC, Tsai PS, Wu CH, Chen HW., Jeng CR, Pang F, Chang HW. Determination of the cell tropism of serotype 1 feline infectious peritonitis virus using the spike affinity histochemistry in paraffin-embedded tissues. Microbiology and Immunology 61:318-327, 2017.
6. 期刊論文 Chattopadhyay S, Chen JY, Chen HW., Hu CMJ. Nanoparticles vaccines adopting virus-like features for enhanced immune potentiation. Nanotheranostics doi:10.7150/ntno.19796, 2017.
7. 期刊論文 Hu CMJ, Chien CY, Liu MT, Fang ZS, Chang SY, Juang RH, Chang SC, Chen HW. Multi-antigen avian influenza A (H7N9) virus-like particles: particulate characterizations and immunogenicity evaluation in murine and avian models. BMC Biotechnology doi:10.1186/s12896-016-0321-6, 2017.
8. 期刊論文 Lin SY, Li YT, Chen YT, Chen TC, Hu CMJ, Chen HW. Identification of an infectious bronchitis coronavirus strain exhibiting a classical genotype but altered antigenicity, pathogenicity, and innate immunity profile. Scientific Reports doi:10.1038/srep37725, 2016.
9. 期刊論文 Elong Ngono A, Chen HW, Tang WW, Joo Y, King K, Weiskopf D, Sidney J, Sette A, Shresta S. Protective role of cross-reactive CD8 T cells against dengue virus infection. EBioMedicine doi:10.1016/j.ebiom.2016.10.006 (2016).
10. 期刊論文 Chen HW*, Huang CY, Lin SY, Fang ZS, Hsu CH, Lin JC, Chen YI, Yao BY, Hu CMJ*. Synthetic virus-like particles prepared via protein corona formation enable effective vaccination in an avian model of coronavirus infection. Biomaterials. doi:10.1016/j.biomaterials.2016.08.018 (2016). (*corresponding)
11. 期刊論文 Chen HW*, Liu PF, Liu YT, Kuo S, Zhang XQ, Schooley RT, Rohde H, Gallo RL, Huang CM*. Nasal commensal Staphylococcus epidermidis counteracts influenza virus. Scientific Reports. doi: 10.1038/srep27870 (2016). (*corresponding)
12. 期刊論文 Chang KP, Kolli BK, Batchu R, Chen HW, Chow LC, Elliott R, Head J, Fan CK, Hung CH, Ji DD, Lun ZR, Manna L, Matsumoto Y, Ng DP,de Oliveira C, Melo S, Ozbel Y, Özbilgin A, Reynolds J, Sanjoba C, Shiao SH, Shih NY, Tsai CW, Vicente MG, Barré C, Volf P, Wu YL, Yu CL, Zhou XN. New "light" for one-world approach toward safe and effective control of animal diseases and insect vectors from leishmaniac perspectives. Parasites & Vectors. doi: 10.1186/s13071-016-1674-3 (2016).
13. 期刊論文 Wang LC, Huang D, Chen HW. Simultaneous subtyping and pathotyping of avian influenza viruses in chickens in Taiwan using reverse transcription loop-mediated isothermal amplification and microarray. Journal of Veterinary Medical Science 78:1223-1228, 2016.
14. 期刊論文 Chen HW, Hsiao TH, Wang CH. Detection of anti-reticuloendotheliosis antibody by enzyme-linked immunosorbent assay using envelope protein expressed in baculovirus. Taiwan Veterinary Journal 42:165-170, 2016.
15. 期刊論文 Chen HW, King K, Tu J, Sanchez M, Luster AD, Shresta S. The roles of IRF-3 and IRF-7 in innate antiviral immunity against dengue virus. Journal of Immunology 191:4194-4201, 2013.
16. 期刊論文 Chen HW, Cheng JX, Liu MT, King K, Peng JY, Zhang XQ, Wang CH, Shresta S, Schooley RT, Liu YT. Inhibitory and combinatorial effect of diphyllin, a v-ATPase blocker, on influenza viruses. Antiviral Research 99:371-382, 2013.
17. 期刊論文 Cohen M, Zhang XQ, Senaati HP, Chen HW, Varki NM, Schooley RT, Gagneux P. Influenza A penetrates host mucus by cleaving sialic acids with neuraminidase. Virology Journal 10:321-333, 2013.
18. 期刊論文 Wu NH, Tsai WT, Chen HW, Wang LC, Wang CH. Detection of anti-reticuloendotheliosis virus antibody by blocking enzyme-linked immunosorbent assay with expression envelope protein. Avian Diseases 57:71-75, 2013.
19. 期刊論文 Huang YP, Chen HW, Wang CH. Review: Worldwide epidemiology of infectious bronchitis virus variants. Taiwan Veterinary Journal 38:258-269, 2012.
20. 期刊論文 Hong HW, Cheng IC, Chen HW, Wang CH. Comparison of NP and M primers for avian influenza virus detection by reverse transcription polymerase chain reaction. Taiwan Veterinary Journal 38:213-220, 2012.
21. 期刊論文 Chen HW, Wang CH, Cheng IC. A type-specific blocking ELISA for the detection of infectious bronchitis virus antibody. Journal of Virological Methods173:7-12, 2011.
22. 期刊論文 Hsu MF, Chen HW, Chen CF, Wang CH. The serologic prevalence of subgroup J avian leukosis virus in some chickens in Taiwan in 2010. Taiwan Veterinary Journal 37:227-223, 2011.
23. 期刊論文 Tsai WT, Chen ZF, Chen HW, Chang SW, Lee GG, Wang CH. Reticuloendotheliosis virus infection in Taiwan Country Chickens. Taiwan Veterinary Journal 37:278-283, 2011.
24. 期刊論文 Chen HW, Wang CH. A multiplex RT-PCR assay for the genotyping of avian infectious bronchitis viruses. Avian Diseases54:104-108, 2010.
25. 期刊論文 Chen HW, Huang YP, Wang CH. Identification of intertypic recombinant infectious bronchitis viruses from slaughtered chickens. Poultry Science 89:439-446, 2010.
26. 期刊論文 Chen HW, Huang YP, Wang CH. Identification of Taiwan and China-like recombinant avian infectious bronchitis viruses in Taiwan. Virus Research 140:121-129, 2009.
27. 研討會論文 Chen YT, Lo CW, Chen HW. Inhibition of influenza A virus by mung bean (Vigna radiata) extract (VIVA) targeting viral attachment, assembly and release. 2019. XXI World of Veterinary Poultry Association Congress. Bangkok, Thailand. (Poster presentation)
28. 研討會論文 Chen YT, Yu FL, Chen HW. Broadly protective efficacy of mung bean feed additive (VIVA) against avian influenza virus, Newcastle diseases virus and infectious bronchitis infections in chicken embryos. 2019. XXI World of Veterinary Poultry Association Congress. Bangkok, Thailand. (Oral presentation)
29. 研討會論文 Huang PH, Tsai HH, Hu CMJ, Chen HW. A virus-mimetic nanoparticle vaccine for Zika virus. 2019. The 18th Awaji International Forum on Infection and Immunity. Awaji Island, Japan. (Oral presentation)
30. 研討會論文 Tsai HH, Liao WT, Chen HW, Hu CMJ. Single dose nanoparticle-based M2e peptide vaccine induces cross-protective immunity against influenza A viruses. 2019. Options X for the Control of Influenza. Singapore. (Poster presentation)
31. 研討會論文 Liao WT, Tsai HH, Lin CW, Chang SC, Hu CMJ, Chen HW. A STING-activating polymeric nanoparticle enhances humoral and cellular immunity against influenza A virus. 2019. Options X for the Control of Influenza. Singapore. (Poster presentation)
32. 研討會論文 Zhu WZ, Wen YC, Chen TC, Lin SY, Chen HW. Avian influenza H6 virus-like particles confers potent immunogenicity and protective efficacy in chickens. 2019. American Association of Avian Pathologists Meeting. Washington DC. (Oral presentation)
33. 研討會論文 Chen YT, Lo CW, Chen HW. Inhibition of influenza A virus by Vigna radiata extract targeting viral attachment, assembly and release. 2019. The 10th Joint Symposium of Veterinary Research in East Asia. Gifu, Japan. (Poster presentation)
34. 研討會論文 Tsai HH, Liao WT, Hu CMJ, Chen HW. M2e peptide-encapsulated nanoparticle vaccine elicits strong and broadly protective immunity against influenza A viruses. 2019. The 10th Joint Symposium of Veterinary Research in East Asia. Gifu, Japan. (Poster presentation)
35. 研討會論文 Hsieh CJ, Hu CMJ, Chen HW. Viral membrane-coated nanoparticles for anti-influenza vaccination. 2019. The 10th Joint Symposium of Veterinary Research in East Asia. Gifu, Japan. (Oral presentation)
36. 研討會論文 Zhu WZ, Wen YC, Chen TC, Lin SY, Chen HW. Anti-influenza efficacy of a virus-like particle and novel nanoformulated adjuvant. 2019. The 10th Joint Symposium of Veterinary Research in East Asia. Gifu, Japan. (Oral presentation)
37. 研討會論文 Chen HW, Tseng CT, Hu CMJ. Viromimetic STING agonist-loaded hollow polymeric nanoparticles for vaccination against Middle East Respiratory Syndrome coronavirus. 2019. Keystone Symposia-Molecular Approaches to Vaccines and Immune Monitoring. Keystone, CO. (Poster presentation)
38. 研討會論文 Huang PH, Tsai HH, Hu CMJ, Chen HW. Investigation of different antigen coating methods on the performance of Zika virus nanoparticle vaccine. 2018. Keystone Symposia-Framing the Response to Emerging Virus Infections. Hong Kong. (Poster presentation)
39. 研討會論文 Lin SY, Yao BY, Hu CMJ, Chen HW. Nanoparticulate CpG enhances chicken immune response. Avian Immunology Research Group 2018. Oxford, UK.
40. 研討會論文 Wen YC, Zhu WZ, Chang CF, Wang CH, Chen HW. Genetics, receptor binding, and pathogenicity investigation of H6 avian influenza virus in Taiwan. 2018. American Association of Avian Pathologists Meeting. Denver, CO.
41. 研討會論文 Chen YT, Hu CMJ, Chen HW. Vacuolar ATPase inhibiting nanoparticles exhibit potent host-targeted antiviral activity against influenza viruses. 2018. Negative Strand Virus Meeting. Verona, Italy
42. 研討會論文 Wu SH, Yang SH, Yang TC, Chen HW. Avian bornavirus infection among psittacines in Taiwan. 2018. The 34th World Veterinary Association Congress. Barcelona, Spain.
43. 研討會論文 Lin SY, Chen YT, Chen HW. Diversity of nsp 3 and nsp 16 of infectious bronchitis virus isolated in Taiwan. 2018. The 9th Joint Symposium of Veterinary Research in East Asia. Seoul, Korea.
44. 研討會論文 Fang ZS, Hsieh CJ, Chen YT, Cheng JY, Yao BY, Hu CMJ, Chen HW. Biomembrane coated nanoparticles for influenza virus targeting and isolation. 2018. The 9th Joint Symposium of Veterinary Research in East Asia. Seoul, Korea.
45. 研討會論文 Zhu WZ, Wen YC, Chen TC, Lin SY, Chen HW. Avian influenza H6 virus-like particles: Immunogenicity evaluation in murine and avian models. 2018. The 9th Joint Symposium of Veterinary Research in East Asia. Seoul, Korea.
46. 研討會論文 Wen YC, Zhu WZ, Chen HW. Genetics, receptor binding, replication and mammalian adaptation of H6 avian influenza viruses in Taiwan. 2018. The 9th Joint Symposium of Veterinary Research in East Asia. Seoul, Korea.
47. 研討會論文 Chen YT, Fang ZS, Chang WS, Chuang HF, Hu CMJ, Chen HW. Antiviral efficacy of diphyllin nanoparticles against influenza viruses. 2018. The 9th Joint Symposium of Veterinary Research in East Asia. Seoul, Korea.
48. 研討會論文 Huang CY, Lin CW, Tseng CT, Hu CMJ, Chen HW. A STING agonist-loaded viromimetic nanoparticle for MERS-CoV vaccination. 2018. The 9th Joint Symposium of Veterinary Research in East Asia. Seoul, Korea.
49. 研討會論文 Chen HW., Wen YC, Zhu WZ. Assessment of Genetic, Antigenic, and Pathological Features of H6 Avian Influenza Virus in Taiwan. 2018. Global Alliance for Research on Avian Diseases. Hanoi, Vietnam.
50. 研討會論文 Huang CY, Lin CW, Hu CMJ, Chen HW. Preparation and characterization of synthetic avian coronavirus-like particle using gold nanoparticles. 2017. Virus-like Particle & Nano-particle Vaccines. Singapore.
51. 研討會論文 Lin SY, Li YT, Chen YT, Chen TC, Hu CMJ, Chen HW. Identification of an infectious bronchitis coronavirus strain exhibiting a classical genotype but altered antigenicity, pathogenicity, and innate immunity profile. 2017. American Association of Avian Pathologists Meeting. Indianapolis, IN.
52. 研討會論文 Chang WS, Wang WL, Fang ZS, Chueh LL, Takano T, Hohdatsu T, Hu CMJ, Chen HW. Nanoparticulate v-ATPase blocker exhibits potent antiviral activity against feline peritonitis virus. 2017. International Union of Microbiological Societies Meeting. Singapore.
53. 研討會論文 Chen HW., Huang CY, Lin SY, Fang ZS, Hsu CH, Lin JC, Chen YI, Yao BY, Hu CMJ. Synthetic virus-like nanoparticles assembled via protein corona formation enable effective antiviral vaccination. 2017. European Material Research Society 2017 Spring Meeting. Strasbourg, France.
54. 研討會論文 Chen HW., Li YT, Chen TC, Tsai HF, Wang CH. Emerging IBV variants: the genotypes, serotypes and pathotypes. 2016. American Association of Avian Pathologists Meeting. San Antonio, TX.
55. 研討會論文 Hu CMJ, Chen HW. Cell membrane cloaked nanoparticles for biologically inspired drug delivery. 2015. The 13th US-Japan Symposium on Drug Delivery Systems. Maui, HI.
56. 研討會論文 Chien CY, Liu MT, Chang SY, Chang SC, Juang RH, Chen HW. Preparation and immunogenicity evaluation of influenza A/H7N9 virus-like particles. 2015. Oxford Influenza 2015. Oxford, UK.
57. 研討會論文 Peng JY, Wang CH, Chen HW. Molecular and serological epidemiology of avian influenza virus subtype H6N1 in Taiwan. 2015. American Association of Avian Pathologists Meeting. Boston, MA.
58. 研討會論文 Jian CZ, Cheng IC, Wang CH, Chen HW. Preparation and characterization of monoclonal antibodies against the nucleocapsid protein of avian infectious bronchitis virus. 2015. American Society for Virology 34th Annual Meeting. London, Canada.
59. 研討會論文 Chen HW, Peng JY, Lee HC, He JL, Huang YP, Wang CH. Evolutionary changes in the receptor-binding site of the hemagglutinin protein in the avian influenza H6N1 virus may contribute to interspecies transmission. 2014. American Association of Avian Pathologists Meeting. Denver, CO.
60. 研討會論文 Chen HW, King K, Tu J, Sanchez M, Luster AD, Shresta S. The roles of IRF3 and IRF7 in innate antiviral immunity against dengue virus. 2013. American Society for Virology 32nd Annual Meeting. State College, PA.
61. 研討會論文 Chen HW, Wang CH. Characterization of hemagglutination activity of infectious bronchitis viruses and cell-associated hemadsorption activity of baculovirus expressed S1 glycoprotein. 2012. American Association of Avian Pathologists Meeting. San Diego, CA.
62. 研討會論文 Chen HW, Wang CH. Development of a type-specific blocking ELISA for the detection of infectious bronchitis virus antibody. 2010. American Association of Avian Pathologists Meeting. Atlanta, GA.
63. 研討會論文 Chen HW, Wang CH. A multiplex RT-PCR assay for the genotyping of avian infectious bronchitis viruses. 2009. American Society for Virology 28th Annual Meeting. Vancouver, Canada.
64. 研討會論文 Chen HW, Huang YP, Wang CH. Avian infectious bronchitis viruses identified in poultry slaughter houses exhibit wide genetic and antigenic varieties. 2009. 6th International Symposium on Avian Corona- and Pneumovirus and Complicating Pathogens. Rauischholzhausen, Germany.
65. 研討會論文 Chen HW, Wang CH. Characterization and application of monoclonal antibodies to avian infectious bronchitis virus. 2007. 15th Congress of the World Veterinary Poultry. Beijing, China.
66. 期刊論文 Lin JC, Chien CY, Lin CL, Yao BY, Chen YI, Liu YH, Fang ZS, Chen JY, Chen WY, Lee NN, Chen HW, Hu CMJ. Intracellular hydrogelation preserves fluid and functional cell membrane interfaces for biological interactions. Nature Communications doi:10.1038/s41467-019-09049-5, 2019.
67. 期刊論文 Lin LCW, Huang CY, Yao BY, Lin JC, Agrawal A, Algaissi A, Peng BH, Liu YH, Huang PH, Juang RH, Chang YC, Tseng CT*, Chen HW*, Hu CMJ*. Viromimetic STING agonist-loaded hollow polymeric nanoparticles for safe and effective vaccination against Middle East respiratory syndrome coronavirus. Advanced Functional Materials doi:10.1002/adfm.201807616, 2019. (*corresponding)
68. 期刊論文 Liu IL, Lin YC, Lin YC, Jian CZ, Cheng IC, Chen HW*. A novel immunochromatographic strip for antigen detection of avian infectious bronchitis virus. International Journal of Molecular Sciences doi:10.3390/ijms20092216, 2019. (*corresponding)
69. 期刊論文 Ho JC, Chen HW, Lin CH, Hu KC. Fluid colour sign on chest ultrasonography in a cat with exudate pleural effusion and pleuropneumonia. Journal of Small Animal Practice doi:10.1111/jsap.13043, 2019.
70. 期刊論文 Li YT, Chen TC, Lin SY, Mase M, Murakami S, Horimoto T, Chen HW*. Emerging lethal infectious bronchitis coronavirus variants with multiorgan tropism. Transboundary and Emerging Diseases doi.org/10.1111/tbed.13412, 2019. (*corresponding)
71. 期刊論文 Liu IL, Chi NY, Chang CL, Hung ML, Chiu CT, Chen HW*. A novel PCR-based point-of-care method enables rapid, sensitive and reliable diagnosis of Babesia gibsoni infection in dogs. BMC Veterinary Research doi.org/10.1186/s12917-019-2181-5, 2019. (*corresponding)
72. 期刊論文 Lin SY, Yao BY, Hu CMJ, Chen HW*. Induction of robust immune responses by CpG-ODN-loaded hollow polymeric nanoparticles for antiviral and vaccine applications in chickens. International Journal of Nanomedicine doi.org/10.2147/IJN.S241492, 2020. (*corresponding)
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